RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally

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RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally

Mutation in RAS proteins is one of the most common genetic alterations observed in human and experimentally induced rodent cancers. In vivo, oncogenic mutations have been shown to occur at exons 12, 13, and 61, resulting in any 1 of 19 possible point mutations in a given tumor for a specific RAS isoform. While some studies have suggested a possible role of different mutant alleles in determinin...

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ژورنال

عنوان ژورنال: Frontiers in Genetics

سال: 2012

ISSN: 1664-8021

DOI: 10.3389/fgene.2011.00100